Crit Ical Issues Facing a N I M a L Scientists 1

An important series of issues confronts the animal research scientist involved in meeting world needs for food products from animal agriculture. The major issues stem from societal pressures for improved products, for prevention of chemical pollution of the biosphere, and for wise use of animal resources in toxicological testing and research. The following issues are among those treated in the present discussion: (1) There is a need to obtain reliable dosage vs response information for chronic effects produced in the human by food additive chemicals. (2) There is a need for toxicological research On combined hazard from multiple contaminants in animal food products. (3) There is a requirement for development of methodology for proper usage and(or)disposal of chemically contaminated animal food products. (4) The public must be educated with respect to the absolute necessity for use of intact animals in biological research, to supplement information from in vitro systems. (5) Animal scientists must characterize fully each animal species and strain employed in research and testing, to guarantee reproducibility of results. (6) Animal scientists must evolve a universal set of principles for translation of animal toxic i ty data into prediction of human hazard. (7) Animal scientists should develop universally uniform methodology for toxicological testing of foods and food chemical residues. (8) Animal scientists should rebut national regulatory philosophies that derive from unsound science. (9) The animal scientist should assist regulatory authorities in developing sound, practical "Good Laboratory Practice" guidelines.